Designing Relocatable Cabins ? Home Improvement: House Plans ...

If you need help to build a relocatable buildings cabin, whether for your primary home or to house a relative that can no longer live on their own, then you are in the right place. There is nothing to building a relocatable cabin as long as you have some basic skills, such as the ability to read a blueprint, and have some power tools to use during the building process.

Plan Your Addition

If you are adding the relocatable cabin to your existing home, then you will want to make a plan for its construction, noting whether you want the cabin to be joined to the existing home, or not. If you simply want an annex further back on the property, you will have a much easier time building than if you would like for the two homes to be joined.

If you are planning on using the cabin for a primary home, then you will want to choose your placement well. Trees can provide shade for the home, and lower cooling costs, in the hot months, while direct sun can lower heating costs during the day.

Choose Your Plan

If you want to use the relocatable cabin for a member of your family, or for yourself, there are plans that will meet your needs easily. You can choose between one and two floor plans, and all of the cabins have steel framing that is both cyclone and termite resistant. No matter where you live, from Queensland to Tasmania, you can definitely find a plan that is perfect for you. All of the materials that you need will be delivered to your door, where you can assemble the home yourself or hire a contractor.

Styling

You will have many different options for the interior of your relocatable cabin. You can choose modern features such as island kitchen sinks and hardwood flooring, as well as built in hair dryers and low energy cooling and heating systems. If you are planning on using the relocatable cabins as an addition to the family home, the low energy features will be a great benefit.

Adding a relocatable cabin to your home also means that, when joining the structures, that you will need to be able to match the exteriors. If you have a more modern exterior of siding, then there may not be much to matching the exteriors. If you happen to have a brick or rock home, then you may want to customize your order to include a matching exterior, or hire a contractor to refurbish the outside of the relocatable cabin.

Interior

Inviting a family member to live with your immediate family does take some planning. Relocatable cabins really do make great granny flats. If you want to join the two homes, you may want to consider matching the interior as well as the exterior. You do want to ask the new member of your family what their preferences are, since the relocatable cabins are an all inclusive home, with everything from the kitchen to the bathroom being available.

Source: http://redtreeinteractive.com/designing-relocatable-cabins/

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Source: http://lannyvinson53.typepad.com/blog/2012/11/designing-relocatable-cabins-home-improvement-house-plans.html

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Source: http://norman8321.typepad.com/blog/2012/11/designing-relocatable-cabins-home-improvement-house-plans.html

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President's backers, rivals clash in Egypt

AAA??Nov. 23, 2012?7:26 AM ET
President's backers, rivals clash in Egypt
By MAGGIE MICHAELBy MAGGIE MICHAEL, Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?

In this Thursday, Nov. 22, 2012 photo, former Egyptian presidential candidate, Hamdeen Sabahi, left, speaks to former director of the U.N.'s nuclear agency and Nobel peace laureate, Mohamed El Baradei, during a news conference flanked by other prominent politicians, not shown, from outside the Muslim Brotherhood, to decry what was interpreted as a de facto declaration of emergency law by Egyptian President Mohammed Morsi, in Cairo Egypt. Egypt's Islamist president unilaterally decreed greater authorities for himself Thursday and effectively neutralized a judicial system that had emerged as a key opponent by declaring that the courts are barred from challenging his decisions. (AP Photo/Mostafa El Shemy)

In this Thursday, Nov. 22, 2012 photo, former Egyptian presidential candidate, Hamdeen Sabahi, left, speaks to former director of the U.N.'s nuclear agency and Nobel peace laureate, Mohamed El Baradei, during a news conference flanked by other prominent politicians, not shown, from outside the Muslim Brotherhood, to decry what was interpreted as a de facto declaration of emergency law by Egyptian President Mohammed Morsi, in Cairo Egypt. Egypt's Islamist president unilaterally decreed greater authorities for himself Thursday and effectively neutralized a judicial system that had emerged as a key opponent by declaring that the courts are barred from challenging his decisions. (AP Photo/Mostafa El Shemy)

In this photo released by the Egyptian Presidency, President Mohammed Morsi, right, poses for a photograph with his new Prosecutor General, Talaat Abdullah, left, in Cairo, Egypt, Thursday, Nov. 22, 2012. Egypt's president on Thursday issued constitutional amendments granting himself far-reaching powers and ordering the retrial of leaders of Hosni Mubarak's regime for the killing of protesters in last year's uprising. Morsi also on Thursday fired the country's top prosecutor by decreeing with immediate effect that he could only stay in office for four years and replacing him with Talaat Abdullah. Morsi fired Abdel-Maguid Mahmoud for the first time in October, but had to rescind his decision when he found that the powers of his office do not empower him to do so. (AP Photo/Egyptian Presidency)

(AP) ? Clashes have erupted between pro-democracy protesters and supporters of President Mohammed Morsi in three Egyptian cities after the Islamist leader assumed sweeping new powers.

Thousands from the two camps threw stones and chunks of marble at each other outside a mosque in the Mediterranean city of Alexandria after Friday Muslim prayers. Anti-Morsi protesters threw stones and firecrackers at supporters of Morsi's Brotherhood, who used prayer rugs to shield themselves.

The anti-Morsi protesters stormed a Brotherhood office in front of the mosque. At least 15 people were hurt in the clash, medical officials said.

Similar clashes erupted in the southern city of Assiut and in Giza, the sister city of the capital, Cairo.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-23-Egypt/id-069a7a5d32bb4328a9b0cec45342a604

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3 Amazing Outfits For The Holiday Season

Fabsugar.com:

A festive cocktail dress is always a safe choice for the holidays.

Read the whole story at Fabsugar.com

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Source: http://www.huffingtonpost.com/2012/11/22/3-amazing-outfits-for-the_n_2176068.html

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CSN: Harbaugh taking unnecessary QB gamble

November 21, 2012, 10:44 pm

Jim Trotter of Sports Illustrated tells us that Jim Harbaugh has demoted Alex Smith for Colin Kaepernick. He also tells us that Smith is trying to be the loyal soldier by backtracking on ESPN?s Trent Dilfer.

[RELATED: Report -- Smith informed Kaepernick will start]

Well, all that means is that Smith doesn?t feel comfortable fighting the power. It does mean, though, that Harbaugh has decided to roll the dice on Kaepernick, and if he?s right, he has a Super Bowl trophy.

And if he?s not, he has created a mess out of which he cannot gobble his way to an escape.

Harbaugh chose to tell Smith Wednesday that he was going with Kaepernick in New Orleans and beyond, concussion clearance or no concussion clearance. He decided that a so-so game against St. Louis and a big game against Chicago was evidence enough to put his championship plans in the hands of a neophyte.

It is a gambler?s move at a time when gambling isn?t required. It is a move that declares the already shiny status quo to be null and void, and it is a move that tells every other player on the roster that yesterday?s deeds do not equal today?s hunch.

And all Kaepernick has to do is win it all for Harbaugh to be beyond bulletproof. He will be Nick Saban, and Urban Meyer, and Chip Kelly, all rolled into one. Invulnerable, even in the face of any and all Yorks. And maybe that?s how it should be in the NFL. In an amoral sport like football, in a soulless organization like the NFL, winning is the one reductive truth that trumps all other behaviors.

But if he?s wrong, if the 49ers aren?t a Super Bowl team after all, if Kaepernick?s 1 ? games of work really are too small a sample size, he won?t be able to gobble or jive his way out of this flightless bird.

And we have no rooting interest either way. We don?t care who wins the hand. We just know that he decided to go all-in trusting only his gut and the gods who handle the flop, turn and river.

He has, in short, revealed his truest nature here. We make no value judgments, but we do know when a guy has decided to gamble on a longshot, and when he needs to do so. This was not that time, but Harbaugh couldn?t wait. He didn?t want people to talk about a quarterback controversy because he knows that it isn?t who talks that?s the problem, but who hears it.

And Smith, based on sources, is not going to object to the change. Whether that makes him a good teammate or a natural-born follower is for others to deduce; psychology isn?t what we do here.

But Harbaugh?s gamble puts the entire team at risk, and it shows that while he is unafraid to make bold moves, it also shows that loyalty is a one-way street. Players suspect that of coaches and general managers all the time, but they file the information away from when the time comes to use it.

And being 7-2-1, going into New Orleans, isn?t that time.

In short, Colin Kaepernick has been given the keys to the Lexus and told he can drive it like a Lamborghini Murcielago. If he wins the race, well, genius has been served. Winners by definition cannot lose.

But if Kaepernick wraps it around a tree, or dunks into a lagoon, or gets hit the wrong way, the fault will not be his, but Harbaugh?s. The coach went all in when he didn?t have to. He could have checked, even check-raised, but he pushed all his chips in because despite the fact that he didn?t have to do it, he did it anyway. He surrendered to an impulse at a time when being impulsive wasn?t really needed.

And impulses sometimes cause scorch marks and scarring.

Source: http://www.csnbayarea.com/11/22/12/Impulsive-Harbaugh-goes-all-in-unnecessa/nbcsportsniners.html?blockID=804951&feedID=2800

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94% Looper

All Critics (231) | Top Critics (41) | Fresh (216) | Rotten (15)

The reasoning behind all this may not reward prolonged inspection, but Johnson is smart enough to press onward with his plot, leaving us with neither the time nor the desire to linger over the logic ...

Writer-director Rian Johnson establishes himself as an original talent who clearly believes storytelling must prevail.

A mind-bending ride that is not afraid to slow down now and again, to explore themes of regret and redemption, solitude and sacrifice, love and loss. It's a movie worth seeing and, perhaps, going back to see again.

Looper has more heart than Brick and the 2008 con-man flick The Brothers Bloom. Both fine achievements, they could also be described as viscerally cerebral.

I'm a sucker for time-travel movies.

Looper felt to me like a maddening near-miss ...

Looper is among the cleverest, most skillfully crafted and entertaining sci-fi thrillers of the past 20 years.

The smartest, most stylish and most outright entertaining science-fiction film of the year.

A thought-provoking, heart-pounding take on the applications and ethics of time travel which, oddly enough, doubles up as a lesson in the importance of good parenting.

This is one of those rare genre movies (like the original TERMINATOR) that reminds us that Sci-Fi can be smart. It's much more than just a bunch of special effects and explosions. It's what all movies should aspire to be.

While it sometimes feels like it's trying to do much, Looper manages to be a creditable and exciting sci-fi flick that homages the past while carving out a unique identity.

Much as he did in Brick, Johnson creates a carefully drawn world in Looper that exists by its own particular set of rules.

... has an irresistible energy and a don't-give-a-damn unpredictability ...

Beautifully crafted, acted and written.

Anchors high-concept thrills and captivating ideas in a world of challenging morality and intricate personal consequences.

Truly imaginative but all the twists and turns make the overall film difficult to follow. Plus Gordon-Levitt has not reached leading man status yet.

Kind of a reverse-"Terminator" without any of James Cameron's wit (or wisdom),

An endlessly creative mind-blowing film that captures everything right about the movie going experience. Johnson conjures up the most imaginative action/science fiction film since 'Inception.'

Part science fiction, part mob movie, and with a nice infusion of dark comedy at just the right moments, Looper is Johnson's best movie yet, and manages to be hugely entertaining, affecting, and thought-provoking.

takes us far beyond the film's high-concept premise into the kind of emotional terrain that too often escapes even the best genre filmmakers

Doesn't quite reach the heights of the lofty ideals that it so ardently seeks to expound, but makes up for this with the sheer thrill of the journey Rian Johnson takes us on.

Ingenious with a fine performance by Emily Blunt, but far too much cold-blooded violence.

Engaging, exciting, and successfully cross-breeding elements of Terminator and even Pet Sematary, Looper is a solid work of palatable science-fiction.

Looper's super. An action-thriller that bothers to have a brain.

Looper may not take us back to the future as satisfyingly as Robert Zemeckis' Marty McFly trilogy or James Cameron's Terminator franchise, but writer-director Rian Johnson does enough right to all but guarantee that he has a future cult film on the books.

The best time travel films play on emotion rather than logic, and once Looper realises this and drops all the tail-chasing about how time travel works it settles into the engrossing action/drama about destiny it should have been from the get go.

Source: http://www.rottentomatoes.com/m/looper/

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Rumor: Microsoft preparing set-top box version of next Xbox, to be revealed pre-holiday 2013

Rumor Microsoft preparing settop box version of next Xbox, to be revealed preholiday 2013

Microsoft may be preparing a lite version of its next-generation console specifically made for set-top box purposes. The Verge says the device -- dubbed "Xbox TV" -- will be part of Microsoft's next-gen console strategy, offering a low-cost alternative to the still unannounced, "Durango" with "access to core entertainment services;" it's also said to be an "always on" device. The report also posits that both Microsoft's next system and this alternate device will be revealed and released ahead of holiday 2013.

It's unclear exactly what the rumored set-top box's "core entertainment services" might be, but it's not hard to imagine it comprising the recently revamped Xbox Video / Music services, as well as the myriad other multimedia services available through the current-gen Xbox 360. The company is also allegedly exploring Xbox TV as a service, licensed out to various television manufacturers and integrated on a software level -- none of this sounds especially far-fetched considering Microsoft's new strategy of marketing the Xbox brand as its entertainment wing, as well as pitching its latest version of Windows as a scalable, multi-device OS.

For Redmond's part, the company's only issuing the following boilerplate statement: "Xbox 360 has found new ways to extend the console lifecycle by introducing controller-free experiences with Kinect and re-inventing the console with a new dashboard and new entertainment content partnerships. We are always thinking about what is next for our platform and how to continue to defy the lifecycle convention." We expect to hear much more rumblings on the

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Source: The Verge


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Daily news roundup: November 20, 2012

ScienceDaily: Gene News

http://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usWed, 21 Nov 2012 23:30:17 ESTWed, 21 Nov 2012 23:30:17 EST60
Media_httpwwwscienced_jpceq
http://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.http://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmhttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmhttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmhttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htmhttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmhttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmhttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmhttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmhttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmhttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmhttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmhttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmhttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmhttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmhttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmhttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmhttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmhttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmhttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmhttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmhttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmhttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmhttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htmhttp://www.sciencedaily.com/releases/2012/11/121113161506.htm Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture, heart attack, cancer, and death.Tue, 13 Nov 2012 16:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121113161506.htmhttp://www.sciencedaily.com/releases/2012/11/121113143656.htm Biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections.Tue, 13 Nov 2012 14:36:36 ESThttp://www.sciencedaily.com/releases/2012/11/121113143656.htmhttp://www.sciencedaily.com/releases/2012/11/121113134807.htm Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.Tue, 13 Nov 2012 13:48:48 ESThttp://www.sciencedaily.com/releases/2012/11/121113134807.htmhttp://www.sciencedaily.com/releases/2012/11/121113134230.htm The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell?s powerhouse, making it dependent on the amino acid glutamine for survival. Depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc. Using Myc-active neuroblastoma cells, a team three priotein executors of the glutamine-starved cell, representing a downstream target at which to aim drugs. Roughly 25 percent of all neuroblastoma cases are associated with Myc-active cells.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134230.htmhttp://www.sciencedaily.com/releases/2012/11/121113134224.htm Even the very lowest levels of radiation are harmful to life, scientists have concluded, reporting the results of a wide-ranging analysis of 46 peer-reviewed studies published over the past 40 years. Variation in low-level, natural background radiation was found to have small, but highly statistically significant, negative effects on DNA as well as several measures of health.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134224.htmhttp://www.sciencedaily.com/releases/2012/11/121113122220.htm Scientists have discovered a new gene that regulates heme synthesis in red blood cell formation. Heme is the deep-red, iron-containing component of hemoglobin, the protein in red blood cells responsible for transporting oxygen in the blood. The findings promise to advance the biomedical community's understanding and treatment of human anemias and mitochondrial diseases, both known and unknown.Tue, 13 Nov 2012 12:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121113122220.htmhttp://www.sciencedaily.com/releases/2012/11/121113122133.htm Researchers have tracked a gene's crucial role in orchestrating the placement of neurons in the developing brain. Their findings help unravel some of the mysteries of Joubert syndrome and other neurological disorders.Tue, 13 Nov 2012 12:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121113122133.htmhttp://www.sciencedaily.com/releases/2012/11/121113091953.htm Why do we get older? When do we die and why? Is there a life without aging? For centuries, science has been fascinated by these questions. Now researchers have examined why the polyp Hydra is immortal -- and unexpectedly discovered a link to aging in humans.Tue, 13 Nov 2012 09:19:19 ESThttp://www.sciencedaily.com/releases/2012/11/121113091953.htmhttp://www.sciencedaily.com/releases/2012/11/121113083536.htm A battle about the ideal height would appear to be raging in men's and women's genes. A researcher in Sweden has shown that this conflict is leading to a difference in reproductive success between men and women of varying height.Tue, 13 Nov 2012 08:35:35 ESThttp://www.sciencedaily.com/releases/2012/11/121113083536.htmhttp://www.sciencedaily.com/releases/2012/11/121112171314.htm A research team has developed a novel device that may one day have broad therapeutic and diagnostic uses in the detection and capture of rare cell types, such as cancer cells, fetal cells, viruses and bacteria.Mon, 12 Nov 2012 17:13:13 ESThttp://www.sciencedaily.com/releases/2012/11/121112171314.htmhttp://www.sciencedaily.com/releases/2012/11/121112171312.htm Tumor cells circulating in a patient's bloodstream can yield a great deal of information on how a tumor is responding to treatment and what drugs might be more effective against it. But first, these rare cells have to be captured and isolated from the many other cells found in a blood sample. Scientists are now working on microfluidic devices that can isolate circulating tumor cells.Mon, 12 Nov 2012 17:13:13 ESThttp://www.sciencedaily.com/releases/2012/11/121112171312.htmhttp://www.sciencedaily.com/releases/2012/11/121112135615.htm Researchers have discovered a new cause for thyroid hormone deficiency, or hypothyroidism. The scientists identified a new hereditary form of hypothyroidism that is more prevalent in males than in females. This sex bias shone a light on where to look for the underlying cause.Mon, 12 Nov 2012 13:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121112135615.htmhttp://www.sciencedaily.com/releases/2012/11/121112135520.htm A new study reveals a genetic link between chronic pancreatitis and alcohol consumption. Researchers found a genetic variant on chromosome X near the claudin-2 gene (CLDN2) that predicts which men who are heavy drinkers are at high risk of developing chronic pancreatitis.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135520.htmhttp://www.sciencedaily.com/releases/2012/11/121112135516.htm Human intelligence and behavior require optimal functioning of a large number of genes, which requires enormous evolutionary pressures to maintain. A provocative theory suggests that we are losing our intellectual and emotional capabilities because the intricate web of genes endowing us with our brain power is particularly susceptible to mutations and that these mutations are not being selected against in our modern society.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135516.htmhttp://www.sciencedaily.com/releases/2012/11/121112135512.htm A new study has found that interleukin-15 (IL-15) alone can cause large granular lymphocytic (LGL) leukemia, a rare and usually fatal form of cancer. The researchers developed a treatment for the leukemia that showed no discernible side effects in an animal model. The study shows that IL-15 is also overexpressed in patients with LGL leukemia and that it causes similar cellular changes, suggesting that the treatment should also benefit people with the malignancy.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135512.htmhttp://www.sciencedaily.com/releases/2012/11/121112135510.htm An emerging tick-borne disease that causes symptoms similar to malaria is expanding its range in areas of the northeast where it has become well-established, according to new research.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135510.htmhttp://www.sciencedaily.com/releases/2012/11/121112135404.htm New evidence indicates that Parkinson's disease is preceded by a period during which healthy regions of the brain take over the functions of damaged ones.Mon, 12 Nov 2012 13:54:54 ESThttp://www.sciencedaily.com/releases/2012/11/121112135404.htmhttp://www.sciencedaily.com/releases/2012/11/121112135229.htm Research has identified a fusion gene responsible for almost 30 percent of a rare subtype of childhood leukemia with an extremely poor prognosis. The finding offers the first evidence of a mistake that gives rise to a significant percentage of acute megakaryoblastic leukemia (AMKL) cases in children. AMKL accounts for about 10 percent of pediatric acute myeloid leukemia (AML). The discovery paves the way for desperately needed treatment advances.Mon, 12 Nov 2012 13:52:52 ESThttp://www.sciencedaily.com/releases/2012/11/121112135229.htmhttp://www.sciencedaily.com/releases/2012/11/121112113133.htm In the first broad genetic landscape mapped of a Burkitt lymphoma tumor, scientists identified 70 mutations, including several that had not previously been associated with cancer and a new one that was unique to the disease.Mon, 12 Nov 2012 11:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121112113133.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

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HP's Autonomy deal highlights pattern of bad ideas

SAN FRANCISCO (AP) ? Hewlett-Packard's $9.7 billion acquisition of Autonomy seemed like a bad idea long before Tuesday's allegations of an accounting scandal made clear it was a deal that should never have happened.

It's the latest in a cavalcade of costly blunders at HP. The Silicon Valley pioneer has squandered billions of dollars on ill-advised acquisitions, compounding the challenges it already faces as it scrambles to adjust to a world that is shifting away from PCs to smartphones and tablets.

On Tuesday, HP took an $8.8 billion write-down for the Autonomy acquisition. Hewlett-Packard Co. CEO Meg Whitman alleged that executives at Autonomy used various accounting tricks to make the British software company appear more profitable.

The Autonomy deal may amplify the pressure on HP to reshuffle its board of directors, which already had been overhauled after a series of previous embarrassments. The debacles, dating back to 2006, include prying into the personal phone records of reporters covering the company to its widely criticized hiring of Leo Apotheker as CEO after the company's previous leader, Mark Hurd, resigned amid questions about his relationship with a female contractor.

Although HP says it was duped into paying too much for Autonomy under the since-fired Apotheker, the deal ultimately was approved by 10 of its current 11 directors, including Whitman, who served on the board for nine months before being appointed as CEO in September 2011

Only shareholder activist Ralph Whitworth wasn't on the board when HP authorized Apotheker to buy Autonomy in August 2011. Just five weeks after the deal was announced, HP's directors fired Apotheker, a move some analysts trace to the company's almost immediate remorse over the Autonomy acquisition.

But Apotheker's ouster may not be enough to placate shareholders who are seething with renewed anger over the deal. The allegation that Autonomy had been "willfully" deceptive leading up to HP's purchase raises the specter of a criminal investigation. It also opens a torrent of potentially distracting class-action lawsuits on behalf of shareholders alleging HP's board was negligent.

"When I talk to investors, that is what they are concerned about: the credibility of the board," said Sterne Agee analyst Shaw Wu. "There already has been a lot of turmoil at this company, but maybe they still need more change."

Wu said he isn't even sure Whitman's job as CEO is safe because of her presence on the board when the Autonomy deal was approved.

In a research note, Topeka Capital Markets analyst Brian White called for a new purge of HP's board.

Whitman said she regrets voting in favor of the Autonomy acquisition while insisting HP did its due diligence. That was an assertion echoed by Apotheker in a prepared statement.

HP Chairman Ray Lane, who joined the board when Apotheker was hired in 2010, still wasn't available for an interview as of late Tuesday, according to company spokesman Michael Thacker.

Mark Williams, a finance professor at Boston University and a former bank examiner for the Federal Reserve, called HP's accusations against Autonomy "due diligence deflection".

"Just to say 'we paid too much because of fraud' doesn't negate the fact of inadequate due diligence," said Williams. "Some responsibility needs to come back to HP."

At least one of HP's board members, McKesson Corp. CEO John Hammergren, has experience the aftermath of an accounting scandal. McKesson named Hammergren as its CEO after revealing it had been conned into buying software maker HBO & Co. for $12 billion in 1999. The accounting fraud wiped out half of McKesson's market value. The San Francisco company has since bounced back under Hammergren, but the comeback took years to pull off.

Investors are losing hope that HP will rebound because the company has made so many questionable decisions in the five years since Apple Inc.'s release of the first iPhone changed the way people use technology. The upheaval has reduced demand for HP's PCs and printers.

"I don't see how anyone could invest in this company any longer," said ISI Group analyst Brian Marshall, who described HP as "an unmitigated train wreck."

HP's stock plunged $1.59, or nearly 12 percent, to finish Tuesday at $11.71. The shares haven't closed this low since October 2002 when HP was still facing a shareholder backlash over its acquisition of rival Compaq Computer.

That deal has turned out better than the acquisitions HP has made during the past five years under three different CEOs. In that time, HP has spent more than $40 billion to buy dozens of companies. In a reflection of how poorly the biggest of those deals have performed, HP's market value has fallen to just $23 billion. That's about 70 percent less than what HP was worth in June 2007 when the first iPhone went on sale.

In the last three months, HP has absorbed nearly $17 billion in non-cash charges to account for the diminished value of its 2008 acquisition of technology consulting service Electronic Data Systems and its 2011 purchase Autonomy. Last year, HP took a nearly $900 million hit for its purchase of device maker Palm Inc.

Other deals for computer networking gear maker 3Com ($2.7 billion deal), data storage service 3Par $2.4 billion) and software maker ArcSight ($1.5 billion) are working out better, so far.

But the Autonomy deal never seemed to make sense to anyone outside HP.

"Something smelled bad about it from the beginning," said 451 Research analyst Alan Pelz-Sharpe, who has been following Autonomy since the company went public in 1998.

Autonomy, which was based in Cambridge, England, had been known for a "dog-eat-dog" sales culture that drove employees to do whatever it took to hit their quarterly targets or risk incurring the wrath of CEO Mike Lynch, Pelz-Sharpe said. "It was never a happy company," the analyst said. "It was always a place where people were frightened to speak out."

Whitman fired Lynch in May because she was frustrated with Autonomy's poor results since the acquisition, which closed less than two weeks into her tenure as HP's CEO. She said she had no idea that she would uncover conduct that led her to allege Autonomy had been fabricating sales before she ousted Lynch. In a statement to the Financial Times, Lynch denied any wrongdoing at Autonomy.

By the spring of 2011, Autonomy was desperately seeking a buyer, according to Oracle Corp. CEO Larry Ellison, whose company has become a bitter HP rival. In a series of statements last year, Ellison said Lynch and investment banker Frank Quattrone tried to persuade Oracle to buy Autonomy. The most serious pitch came in an April 1, 2011 meeting, according to Ellison, who described Autonomy's asking price as "absurdly high."

Quattrone, who faced charges of misconduct for his handling of IPOs during the Internet boom in the late 1990s, and Lynch have acknowledged meeting with Oracle executives. But they have denied offering to sell Autonomy.

HP wound up buying Autonomy at a price that was 64 percent above the company's market value. On the same day the Autonomy deal was announced, Apotheker also revealed he was scrapping HP's attempt to sell mobile devices running on Palm's software. He also said he was mulling a possible sale of the PC division. All those developments stunned investors, leading to a one-day drop of 20 percent in HP's stock price.

Even if HP's board had doubts about the Autonomy deal after Apotheker's exit, the company probably had little choice but to consummate it because the laws of England make it difficult to renege once an offer is made, Pelz-Sharpe said. "About the only way you can do it is if you can prove fraud has been committed."

__

AP Technology Writer Barbara Ortutay in New York contributed to this story.

Source: http://news.yahoo.com/hps-autonomy-deal-highlights-pattern-bad-ideas-235319096--finance.html

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