Israel indicts ex-minister Lieberman

FILE - In this Tuesday, April 17, 2012 file photo, Israeli Foreign Minister Avigdor Lieberman leaves a press conference after meeting with Cyprus foreign minister Erato Kozakou Marcoullis, unseen, at Foreign house in Nicosia, Cyprus. Lieberman was formally indicted on Sunday, Dec. 30, 2012 on charges of breach of trust and fraud, allegations that could hurt his political future if he is convicted. (AP Photo - Petros Karadjias)

JERUSALEM (AP) ? Israel's Justice Ministry filed its indictment against former Foreign Minister Avigdor Lieberman in a Jerusalem court on Sunday, charging him with breach of trust and fraud in a case that could further harm his political career.

Lieberman is accused of trying to advance the career of a former diplomat after the envoy relayed information to him about a criminal investigation into the former Cabinet minister's business dealings.

On Dec. 13, the Justice Ministry released a draft indictment to both Lieberman and the press. On Sunday, an amended version of that draft was filed in the Jerusalem Magistrates Court after prosecutors received testimony suggesting he was more deeply involved than previously thought in trying to promote the diplomat.

The actual charges remained unchanged.

Lieberman, who denies any wrongdoing, resigned his Cabinet post earlier this month after he was informed of the pending charges, though he remains a member of parliament. He did not appear in court on Sunday and had no comment on the indictment.

The diplomat he tried to promote, former ambassador to Belarus Zeev Ben-Aryeh, reached a plea bargain with the state in the case earlier this year.

The indictment did not address the main suspicions against Lieberman that were the focus of a years-long investigation. Attorney General Yehuda Weinstein ultimately decided that prosecutors did not have a strong enough case to charge Lieberman with illicitly receiving millions of dollars from businessmen and laundering the cash through straw companies in eastern Europe.

While he was charged with lesser offenses, Lieberman's political future could be compromised if the court that hears the case decides to convict him of a crime that carries what is known in Israeli law as "moral turpitude." Lawmakers convicted of such crimes must resign immediately from parliament, then are barred from re-entering politics for seven years.

Lieberman's Yisrael Beiteinu party is running on a joint list with Prime Minister Benjamin Netanyahu's Likud in the Jan. 22 election, and he is expected to be re-elected to parliament. Political commentators had viewed the hookup as grooming him to become a future prime minister. Lieberman takes a hard line on concessions to the Palestinians and perceives Israel's large Arab minority as a threat to the Jewish state.

In other political news, Israel's Supreme Court unanimously rejected an election committee's attempt to disqualify an Arab lawmaker from running for parliament again next month because she took part in a flotilla that tried to breach Israel's naval blockade of the Hamas-run Gaza Strip.

The lawmaker, Hanin Zoabi, enraged many Israelis in 2010 by joining the Turkish-led Mavi Marmara flotilla, which was stormed by Israeli naval commandos who clashed with pro-Palestinian activists, killing nine. The Israeli military says the soldiers acted in self-defense after being attacked on the deck.

Zoabi was nearly assaulted in parliament by another lawmaker and subsequently was stripped of some of her parliamentary privileges.

Earlier this month, an Israeli elections committee voted to disqualify her from running in next month's election. She appealed that decision to the Supreme Court, which overturned it, as it has rejected the committee's attempts in previous years to bar other Arab candidates from running.

"I welcome the ruling," Zoabi said. "I hope this ruling will put an end to the political witchhunt."

Lawmaker Danny Danon, who collected thousands of signatures demanding that Zoabi's candidacy be disqualified, accused the court of "backing the Marmara terrorist rather than naval commando fighters."

The court said in its ruling that it would release its reason for overturning the decision at a later date. Under Israel's election law, the court had to issue its ruling by Sunday.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://enews.earthlink.net/article/int?guid=20121230/e9df9add-fb19-4d3a-af33-03bad4d63bb7

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Hasina, Ashraf reelected AL president, secy

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Source: http://www.newstoday.com.bd/index.php?option=details&news_id=2332889&date=2012-12-30

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Jumio Expands, But Mobile Finance Offers Little Opportunity | Credit ...

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Get the best money tips at Credit Visionary

Jumio has made tremendous strides with their credit card scanning software, and now more than 20 new companies will use Netswipe and Netverify for onsite credit card purchases. Jumio?s credit card scanning solution, which we detailed in July of 2011, has appealed to a mass of startups who will join the larger Travelocity and Western Union in using the software.

?The payment processing is safe and very easy to implement for any online company taking payments by credit card,? which is basically everyone nowadays, said Marc Barach, CMO at Jumio in a phone interview. GoPago, a company that has built their business based on the premise that coffee shop patrons need easier and quicker access to lattes through cell phone payments, has chosen to leverage the Netswipe technology.

If you thought GoPago was cool before this, you will never want to buy coffee with cash again. Anyone who has already decided to buy coffee before even getting into the store clearly has no time to type in any credit card information. And now they don?t even have to ? Netswipe uses the phone?s camera to scan the credit card.

While these technologies seem to go hand in hand with one another, they still only marginally approach the mobile wallet vision. E-commerce, mobile finance, mobile payments and whatever other terms you want to throw in for good measure, seem to have hit a ceiling at providing really fast and convenient coffee orders. Where is the promised grocery store revolution, with no checkout lines and payments straight from the phone? What happened to giving your cellphone to your waiter to pay for the check after dinner?

While Jumio?s efforts meld seamlessly into the current mobile finance arena, the level of play is still infantile. We have yet to see a solution that will extend credit through a mobile payments app based on spending history. The so-called ?alternative credit score,? based on on-time payments for utilities and phone bills, is still just a myth. While credit card companies have limited access to a crucial spending demographic thanks to the CARD Act, a company like Google has exactly the right platform to marry the two together.

Google does not have to become a payments company to extend credit. If it tracks the payments of its users through the phone, it should know whether they are creditworthy or not. A simple pilot program could extend credit to college students without access to credit cards and see how well they respond. Better yet, Google already has the physical card.

The mobile payments industry cannot sustainably rest on a community of coffee drinkers. The limited scope of payments and users almost harms the efforts by reporting back such narrow data. It also inadvertently leads companies like Jumio to enter and complement the trends instead of improving them. While Jumio has certainly made its mark by signing with Travelocity and speeding up and securing the checkout process, it doesn?t add up to the mobile finance space that we all dream about.

Article Source

Source: http://www.creditvisionary.com/jumio-expands-but-mobile-finance-offers-little-opportunity?utm_source=rss&utm_medium=rss&utm_campaign=jumio-expands-but-mobile-finance-offers-little-opportunity

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Local sports briefs for Dec. 31

Redbank Valley Holiday Tournament

NEW BETHLEHEM ? Berlin had 12 placewinners, including three champions, and finished second in the team standings on Saturday at the Redbank Valley Holiday Wrestling Tournament.


Chris Miller (132 pounds), Blake Miller (152) and Stew Trulick (195) all captured titles to lead the Mountaineers.

Other placewinners for the Mountaineers were Emil Kiesnowski (106, 8th), Tommy DeArmitt (113, 4th), Joey Swank (120, 4th), E.J. Custer (126, 2nd), Braden Fochtman (138, 6th), Eric Darr (145, 4th), Bryce Fochtman (160, 3rd), Trevor Moore (170, 5th) and Mitchell Walker (220, 2nd).

The top five out of 16 teams were Redbank Valley (271 points), Berlin (212), Cocharton (168.5), Kane (139.5) and Smethport (136.5).

Southmoreland Holiday Classic

ALVERTON ? North Star and Meyersdale were among the 34 teams competing in the Southmoreland Holiday Classic wrestling tournament on Saturday.

North Star?s Levi Albright led the way by claiming the 220-pound title.

Other placewinners for the Cougars were Tayte Mostoller (120, 7th), Tevin Mostoller (138, 6th) and Cory Fritch (152, 8th).

Tanner Hetrick earned runner-up honors at 132 pounds for Meyersdale.

Other placewinners for the Red Raiders were Billy Charlton (113, 3rd), Collin Day (126, 5th), Gavin Berkley (182, 3rd) and Justin Dunmeyer (285, 8th).

Meyersdale was sixth in the final team standings. North Star finished 14th. The top three teams were Butler, Mount Pleasant and Greenville.

Turkeyfoot Christmas Tournament

HARNEDSVILLE ? The Turkeyfoot Valley Boosters Christmas girls basketball tournament is scheduled to conclude today.

Paw Paw (W.Va.) and Union (W.Va.) will meet in the consolation game at 11 a.m.

Salisbury and Turkeyfoot will play for the championship at approximately 12:15 p.m.

Mountain Bowmen shooting schedule

BERLIN ? The Mountain Bowmen Club match shooting schedule for 2013:

Winter 600 league starts Wednesday, Jan. 2. Start time is 7 p.m. (Alternating weeks five-spot target and three-spot target).

Sunday, Jan. 13, five-spot 300 shoot. Start times 9 a.m. and 1 p.m.

Sunday, Feb. 3, three-spot 600 shoot. Start times 9 a.m. and 1 p.m.

Sunday, Feb. 17, five-spot 300 shoot. Start times 9 a.m. and 1 p.m.

Sunday, Aug. 11, 3D-shoot, 8 a.m. to 1 p.m.

Sunday, Aug. 25, 3D-shoot, 8 a.m. to 1 p.m.

Sunday, Sept. 8, 3D-shoot, 8 a.m. to 1 p.m.

Sunday, Sept. 22, 3D-shoot, 8 a.m. to 1 p.m.

For more information contact Mark Cole at kcole10@verizon.net.

Source: http://feedproxy.google.com/~r/SportsFromWwwdailyamericancom/~3/oV_MQ-FeTY0/da-ot-local-sports-briefs-for-dec-31-20121230,0,7546787.story

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Couples wed as gay marriage comes to Maine

Robert F. Bukaty / AP

Steven Bridges, left, receives a wedding ring from Michael Snell, early Saturday at City Hall in Portland, Maine.

By NBC News wire services

PORTLAND, Maine - Gay and lesbian couples exchanged their vows early Saturday as Maine's new same-sex marriage law took effect a minute after midnight.

Among them were Steven Bridges and Michael Snell, who held a commitment ceremony six years ago but wanted to make their marriage official under state law.

"It's historic. We've waited our entire lives for this," said Bridges, a retail manager, who's been in a relationship with the Snell, a massage therapist, for nine years. Bridges, 42, and Snell, 53, wore lavender and purple carnations on black T-shirts with the words "Love is love."

With Snell's two adult daughters looking on, they exchanged their vows in the city clerk's office after getting the first marriage license issued to a same-sex couple in Portland. They said they'll hold another ceremony with friends this summer, after the weather warms up.

Voters approved gay marriage in November, making Maine and two other states the first to do so by popular vote. A law is already in effect in Washington state; Maryland's takes effect Tuesday.?

Nine of the 50 U.S. states plus the District of Columbia, have now legalized gay marriage. Another 31 states have passed constitutional amendments banning it.

In Portland, a half dozen couples huddled with friends and family in freezing temperatures outside the building before the doors to the city clerk's office were opened at 10 p.m. local time.


"We've been together for 30 years, and never thought that this country would allow marriages between gay couples," said Roberta Batt, 71, an antiques dealer and retired physician with silver hair and round eyeglasses. She planned to marry her longtime partner, Mary, who stood nearby.

"We're just very thankful to the people of Maine, and I hope the rest of the country goes the way this state has," she added.

Suzanne Blackburn and Joanie Kunian, of Portland, were among those in line to get their license at midnight, but they didn't plan to wed immediately. One of their grandchildren wanted them to get married on Valentine's Day.

"I don't think that we dared to dream too big until we had the governor's signature," Blackburn said. "That's why it's so important, because it feels real."

Watch the most-viewed videos on NBCNews.com

In Bangor, the city clerk's office was planning to be open on Saturday from 6 a.m. to 8 a.m. for residents to obtain marriage licenses. The Brunswick town clerk's office was set to be open from 9 a.m. to noon on Saturday by appointment. As of midday on Friday, five same-sex couples had booked appointments, the office said.

Robert F. Bukaty / AP

Sarah Dowling, left, speaks Nov. 1 at a gay marriage rally, accompanied by her partner of 18 years, Linda Wolfe, and their daughter, Maya Dowling-Wolfe, in Portland, Maine. Dowling and Wolfe planned to marry after a law allowing same-sex marriage took effect at 12:01 a.m. Saturday.

More lavish same-sex weddings are being booked starting in the spring at the On the Marsh Bistro in Kennebunk, said owner Denise Rubin.

"We support it wholeheartedly," she said. "We look forward to being part of a whole new wave of wonderful thinking."

The tide of public opinion has been shifting in favor of allowing same-sex marriage. In May, President Barack Obama became the first U.S. president to say he believed same-sex couples should be allowed to get married.

A Pew Research Center survey from October found 49 percent of Americans favored allowing gay marriage, with 40 percent opposed. The U.S. Supreme Court has agreed to review two challenges to federal and state laws that define marriage as a union between a man and a woman.

Just a day after Washington became the latest state to allow gay couples to marry, the U.S. Supreme Court will take a serious look at same-sex marriage for the first time ever. NBC's Pete Williams reports.

The nation's highest court said this month it will review a case against a federal law that denies married same-sex couples the federal benefits that heterosexual couples receive. It also will look at a challenge to California's ban on gay marriage, known as Proposition 8, which voters narrowly approved in 2008.

Washington state's law legalizing same-sex unions took effect on Sunday, December 9, and Maryland's law takes effect on January 1, 2013.

This article includes reporting by Reuters and The Associated Press.

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Source: http://usnews.nbcnews.com/_news/2012/12/29/16225220-gay-marriage-comes-to-maine-couples-wed-when-law-takes-effect-after-midnight?lite

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Japan plans to launch asteroid sampling mission in 2014, Time to switch from mega-solar projects to small scale

Japan Launching Ambitious Asteroid-Sampling Mission in 2014

Japan?s space agency is readying a new asteroid probe for launch, an ambitious mission that aims to build on the victory of the country?s first round-trip asteroid mission that sent the Hayabusa spacecraft to retrieve samples of the space rock Itokowa.

The new Japanese asteroid mission, called Hayabusa2, is scheduled for launch in 2014 and aimed at the asteroid 1999 JU3, a large space rock about 3,018 feet (920 meters) in length. It is due to arrive at the asteroid in mid-2018, loiter at the space rock and carry out a slew of challenging firsts before departing the scene at the end of 2019.

If all goes well, the Hayabusa2 spacecraft will return to Earth with samples of asteroid 1999 JU3 at the end of 2020. The probe?s name is Japanese for ?Falcon2.?

An artist?s illustration of Japan?s Hayabusa2 probe crashing an impactor into the asteroid 1999 JU3 ahead of sampling the space rock in 2018. CREDIT: JAXA/Akihiro Ikeshita

There was a recent New York Times piece on the future of asteroid mining ? A Start-Up Sees a Gold Rush Among the Stars. The NYT article gets into the financial feasibility and the technological challenges. Some very bright people including James Cameron and Goggle executives are enthusiastic about the possibilities. Though there are also some scientists who think the scientific and technological breakthrough required for large scale mining may be much further off than the enthusiasts believe. Space craft have been proven able to get to asteroids and bring back samples at least. The initial Hayabusa mission launched in May 2003, returned samples of the asteroid Itokawa. Which were the first asteroid samples ever collected in space ? in June 2010. The top link goes into detail about the Hayabusa2 mission, including how it will make contact, blow out a small crater and collect samples that have not been weathered by space, just below the surface.

This article sounds like me in a cranky mood wondering why we?re not putting more emphasis on individualized solar projects at least in addition to, if not instead of these super large solar farms, Small-scale solar?s big potential goes untapped. Modest-size projects can produce electricity at a lower cost to consumers and the environment, but financing goes to big plants.

The Obama administration?s solar-power initiative has fast-tracked large-scale plants, fueled by low-interest, government-guaranteed loans that cover up to 80% of construction costs. In all, the federal government has paid out more than $16 billion for renewable-energy projects.

Those large-scale projects are financially efficient for developers, but their size creates transmission inefficiencies and higher costs for ratepayers.

Smaller alternatives, from rooftop solar to small- and medium-sized plants, can do the opposite.

Collectively, modest-sized projects could provide an enormous electricity boost ? and do so for less cost to consumers and less environmental damage to the desert areas where most are located, say advocates of small-scale solar power.

Recent studies project that California could derive a substantial percentage of its energy needs from rooftop solar installations, whether on suburban homes or city roofs or atop big-box stores.

One defense of the large projects and loans to large companies is that it created jobs while also fast tracking some new technological development. So it is difficult for me at least to say that such an approach was all bad. Though now is as good a time as any to start to diversify investment in what will become the new energy infrastructure of this century. One of the other factors that made these large corporate solar farms a priority was cost efficiency. The larger the project ? kind of like buying in bulk at the local discount club ? the lower the cost per kilowatt. Much of the technology that was new and expensive just four or five years ago has gotten much cheaper, making roof top solar for homes, big box stores and office parks just as cost efficient as these large projects. On the national level there is little hope ? until the 2014 mi-term elections and getting more pro clean energy representatives in the House ? for any federal incentives for a shift in direction. Conservatives just yesterday proposed holding the debt ceiling hostage in exchange for increasing the Social Security benefit retirement age. These are not the kind of forward thinking or fair minded people that will pass any kind of new solar incentives.

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Can anyone guess what kind of creature is in this photograph. I will give one hint. It is not a snake. You can get the answer here or wait until Monday when I post it.

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Source: http://tangledwing.wordpress.com/2012/12/29/japan-plans-to-launch-asteroid-sampling-mission-in-2014-time-to-switch-from-mega-solar-projects-to-small-scale/

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A Home Tour at Marsha's

Marsha Merry Christmas

?I always like visiting better after Christmas,? said friend Marsha. ? After thinking about it, I do agree. ?The pressure is gone, and one can relax and enjoy being with ones you love. That is when Marsha invited me over for coffee, and I was beyond excited. ?I jumped at the invitation, and offered to bring some Hungarian Butterhorns. ?It is always a joy and a pleasure to visit Marsha. ?I call her my cheerleader. ?She encourages me, writes better comments than I do blogs, and promotes Lanabird. ?Words can not express how thankful I am to her.

Not only is she a totally wonderful person, she has a beyond wonderful home. ?I took pictures so you can visit also.

Be still my heart! ?For years I have admired English chimney pots, and look what greeted me at the front door. ?Filled with oversized ornaments, it is festive and fantastic.

The painted wardrobe from Germany is breathtaking. ?I like it. I love it. ?I do believe it is the prettiest one I have ever seen.

Beyond fantastic are the three wise men on her mantle. ?Marsha said she got them years ago at The Market at North Park. ?I love it that the camels are wearing the crowns.

Looking from her dining room into the den, you can get a sense of how beautiful her home is. ?Isn?t that the most gorgeous antique chandelier?

Be still my heart! ? ?The antique turkey platter takes my breath away. ?It was from Bob?s (Marsha?s husband) family. ? ?Most of the antiques in her home are family heirlooms.

Mercury glass, a mirrored tray, and glittery silver trees are beautiful on the sofa table.

Next to the sofa table is a darling little chair holding a lit tree. ?How cute is that!

I love, love, love, this blue and ?white platter filled with candy canes and red and white glass balls.

Gorgeous ? just gorgeous. ?Marsha had a beautiful antique bowl filled with large pine cones and silver stars.

Marsha and Bob added on a large room on the back of their home. ?It is perfect for entertaining. ?Love the leaded glass side windows (I know they have a name, but I do not know the name.)

Guarding the back door is the most adorable snowman in an antique cart. ?He was handmade by a lady in McKinney.

In several places in her home, Marsha used architectural pieces above mirrors, pictures, and doors. ?The details in her home are amazing.

In the living room there was another small lit tree. ?What a wonderful look.

Sweet Mother of Pearl. ?On the side table, is the happiest Holy Family I have ever seen. ?The smile on Mary and Baby Jesus make me smile. ?I know Joseph is smiling under his beard. ?This reminds me of Marsha. ?She is always happy and smiling. ?Marshachristmas is how she is known on the comment page, and I must say she is a gift to all who know her.

Honestly it was hard for me to leave because I kept seeing more and more unusual things. ?The little tree on the right with the fruit was Bob?s mothers ? probably from the 1940?s. ?I love it, and I love that they still have it.

Amazing! ?Marsha even has a Crawford biscuit tin.

Marsha and Bob are one of the most loved and respected couples I have ever known. ?Thank you for letting me share your home. ?I had such a good time visiting with you, and eating your delicious pimento cheese sandwiches. ?I know I missed many things. ?Your home is truly wonderful.

Blessings to you and yours,

?

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Source: http://www.lanabird.com/2012/12/29/a-home-tour-at-marshas/

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Gen. Norman Schwarzkopf Was a Soldier's General

Yahoo News asked veterans for their thoughts and appreciations of Gen. Norman Schwarzkopf, who died Thursday at 78.

COMMENTARY | It was truly sad to see the announcement of the passing of Norman Schwarzkopf. As a military retiree and a Vietnam veteran, I believe I could understand, empathize and cheer on the general when he lead the forces that liberated Kuwait from the savage Iraqi occupation in 1990.

The contrast between the military campaigns in the Vietnam and Iraq wars is striking, as the former put severe constraints on the military commanders and was orchestrated by Robert McNamara and his so-called civilian "Whiz Kids" back in the comfortable offices in Washington, D.C., while the latter gave Schwarzkopf a great deal of latitude for his planning and execution of his strategy. And history has written it was a brilliant, successful one at that.

Having been in the Air Force for 35 years, I've had a front-row seat to various styles of military leadership, with my insight being honed as time went on and I rose through the ranks. To quote a former commander of mine, "I know what good looks like." General Schwarzkopf was not only good, he was great.

One thing I do know is that the general wasn't a "perfumed prince." He didn't rise rapidly through the officer ranks by being a "yes" man, by keeping his thoughts to himself for fear of offending a superior and certainly not by subscribing to the ever-increasing political correctness in the military.

Yes, he was prone to thunderous outbursts at times, and even had his moments of emotional crisis during his calls with Gen. Colin Powell from his bunker. But that's what made him a military diamond in the rough. While other generals were polished, people discovered more facets of Schwarzkopf: his superb leadership with the troops and officers and his unflagging patriotism while in uniform and later in retirement.

RIP, Sir...

Source: http://news.yahoo.com/gen-norman-schwarzkopf-soldiers-general-164800070.html

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Ouya developer kits are shipping, $99 Android game console ...

The makers of the Ouya video game console have started shipping developer kits to folks who paid $699 or more during the team?s successful Kickstarter campaign. The company plans to start shipping Ouya units to customers early in 2013, with the video game console selling for about $99 plus shipping.

ouya

SlashGear reports the first units should begin arriving this week.

The Ouya game console is a small box with an NVIDIA Tegra 3 quad-core processor, 1GB of RAM, 8GB of storage, WiFi, Bluetooth, a USB 2.0 ports, Ethernet, and HDMI ports.

It runs Google Android software, but it?s not a phone or a tablet. Instead the Ouya console is designed to be plugged into your television so you can play games on the big screen. It also includes a wireless game controller, a game store, and more.

The developer consoles come with two controllers ? but their main appeal is that they?re shipping a few months ahead of the final units, which should give game developers (or serious enthusiasts) a chance to try out the device before it?s available to the general public, and adapt games to run on the platform.

While there?s no shortage of video game consoles for the living room, the developers of the Ouya project want to lower the barriers to entry for independent game developers. Basically, if you can create a game that runs on Android, it can run on Ouya ? you don?t need to go through the hassle of signing with a game publisher, packaging the title on a disc and distributing it to game stores.

On the other hand, the Ouya is expected to ship to regular customers in early 2013 with hardware that was state of the art in early 2012. While you can still write some pretty nifty games for the Tegra 3 processor, Samsung and Qualcomm are already offering mobile processors with significantly more graphics power, and NVIDIA is expected to launch a Tegra 4 chip soon.

Will the Ouya feel dated by the time it finally arrives? Then again? with a $99 price tag, does it really matter?

via SlashGear and Ouya Forum

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  • key specs
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  • Game formatDownloadable
  • Drive capacity8 GB
  • Controller typeWireless
  • Video outputsHDMI
  • Announced07/10/2012
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Source: http://liliputing.com/2012/12/ouya-developer-kits-are-shipping-99-android-game-console-coming-in-2013.html

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Genetic sequencing breakthrough to aid treatment for congenital hyperinsulinism

Dec. 27, 2012 ? Congenital hyperinsulinism is a genetic condition where a baby's pancreas secretes too much insulin. It affects approximately one in 50,000 live births and in severe cases requires the surgical removal of all or part of the pancreas.

Researchers at the University of Exeter Medical School are the first in the world to utilise new genetic sequencing technology to sequence the entirety of a gene in order to identify mutations that cause hyperinsulinism. Previously, existing technology limited such sequencing to only part of the coding regions of the gene which meant that some mutations were missed.

Using new Illumina genetic sequencing technology, the research team led by Professor Sian Ellard has discovered novel mutations that cause hyperinsulinism. Their findings are published December 27 2012, on-line by The American Journal of Human Genetics.

The outcome will be that some infants born with hyperinsulinism will require fewer investigations, because the new technology means that for many only one genetic test will be required to determine the extent of the condition in each child. It also means that clinicians will have more information at their fingertips to inform them about how much of the pancreas needs to be removed.

Approximately 50 per cent of patients with congenital hyperinsulinism require surgery, and of those half require the entire pancreas to be removed. Removal of the entire pancreas increases the risk of diabetes later in life, but if left undiagnosed and untreated hyperinsulinism can result in irreparable brain damage. Symptoms range from shakiness and tiredness to seizure and coma.

Dr. Sarah Flanagan, Research Fellow in Molecular Genetics at the University of Exeter Medical School said: "The potential provided by this new technology is important and exciting, because it allows us to investigate genetic coding in its entirety. This means that investigators can identify mutations that sit at the heart of any number of conditions where before they might have been missed. This in turn results in better information for clinicians upon which they can base effective treatments and interventions for their patients."

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Story Source:

The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Sarah?E. Flanagan, Weijia Xie, Richard Caswell, Annet Damhuis, Christine Vianey-Saban, Teoman Akcay, Feyza Darendeliler, Firdevs Bas, Ayla Guven, Zeynep Siklar, Gonul Ocal, Merih Berberoglu, Nuala Murphy, Maureen O?Sullivan, Andrew Green, Peter?E. Clayton, Indraneel Banerjee, Peter?T. Clayton, Khalid Hussain, Michael?N. Weedon, Sian Ellard. Next-Generation Sequencing Reveals Deep Intronic Cryptic ABCC8 and HADH Splicing Founder Mutations Causing Hyperinsulinism by Pseudoexon Activation. The American Journal of Human Genetics, 2012; DOI: 10.1016/j.ajhg.2012.11.017

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